Erlanger Microlightguidephotometer: a new way of monitoring local oxygen supply of tissue

Jens Adler; Stefan Kuchenruether; W. Doblanzki; M. Georgieff

doi:10.1117/12.230003

15 January 1996 Erlanger microlightguide photometer: a new way of monitoring local oxygen supply of tissue

Jens Adler, Stefan Kuchenruether, W. Doblanzki, M. Georgieff

Proceedings Volume 2628, Optical and Imaging Techniques for Biomonitoring; (1996) https://doi.org/10.1117/12.230003
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Up to now objective criteria for the oxygen supply of tissue only arose from global parameters, for example heart-rate, blood-pressure, blood gases. A judgement of the local oxygen supply -- as an early indicator of organ dysfunction -- is almost impossible. The development of the Erlanger microlightguide photometer (EMPHO) for the first time allows the registration of local parameters as intracapillary hemoglobinoxigenation (HbO₂). The instrument enables the measurement of hemoglobin spectra in tissue micro volumes and thus resolves the spatial heterogeneity of HbO₂. Measurements were performed in healthy human volunteers. HbO₂ was monitored at six points in the skin of the back of the hand. At each measuring site 2000 spectra were recorded. The measurements were performed during normoxia as well as during a period of hypoxia (FiO₂ equals 0.1). It could be shown that changes in the distribution of HbO₂ occur as an indicator of activated local regulatory mechanisms. This opens up the possibility of using the EMPHO for other organs, in order to investigate the relevance of these regulatory mechanisms under physiological and pathophysiological conditions.

Citation Download Citation

Jens Adler, Stefan Kuchenruether, W. Doblanzki, and M. Georgieff "Erlanger microlightguide photometer: a new way of monitoring local oxygen supply of tissue", Proc. SPIE 2628, Optical and Imaging Techniques for Biomonitoring, (15 January 1996); https://doi.org/10.1117/12.230003

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