Photodynamic therapy with photofrin II derivative in the treatment of carcinosarcoma of rats with diabetes mellitus

Vasile F. Dima; Virgil V. Vasiliu; Mircea D. Ionescu; Dezideriu Laky

doi:10.1117/12.203586

8 March 1995 Photodynamic therapy with photofrin II derivative in the treatment of carcinosarcoma of rats with diabetes mellitus

Vasile F. Dima, Virgil V. Vasiliu, Mircea D. Ionescu, Dezideriu Laky

Author Affiliations +

Proceedings Volume 2461, ROMOPTO '94: Fourth Conference in Optics; (1995) https://doi.org/10.1117/12.203586
Event: ROMOPTO '94: 4th Conference on Optics, 1994, Bucharest, Romania

Abstract

Four batches of Wistar rats with Walker-256 carcinosarcoma were used to test the effects of PDT upon `in vivo' tumor growth. Ten days after tumor transplantation, rats from batch I(DM) were exposed to Photofrin II (20 mg/kg), given i.p. 24 h before exposure to laser (632.8 nm; 10 mw; He-Ne laser), five doses given at 4 days intervals; batch II and batch III received sole treatment (DM or PDT). The control batch IV included animals with untreated Walker-256 tumors. The animals were followed up 42 days.

Citation Download Citation

Vasile F. Dima, Virgil V. Vasiliu, Mircea D. Ionescu, and Dezideriu Laky "Photodynamic therapy with photofrin II derivative in the treatment of carcinosarcoma of rats with diabetes mellitus", Proc. SPIE 2461, ROMOPTO '94: Fourth Conference in Optics, (8 March 1995); https://doi.org/10.1117/12.203586

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