Pharmacokinetic studies of delta-aminolevulinic-acid-induced protoporphyrin IX build-up in some malignant tumors

Katarina Svanberg M.D.; Laudelina Pais Clemente; Manuel P. Clemente; Ingrid Wang-Nordman; Trond Warloe; Stefan Andersson-Engels; Roger Berg; Johan Moan; Qian Peng; Sune Svanberg

doi:10.1117/12.206834

12 April 1995 Pharmacokinetic studies of δ-aminolevulinic-acid-induced protoporphyrin IX build-up in some malignant tumors

Katarina Svanberg M.D., Laudelina Pais Clemente, Manuel P. Clemente, Ingrid Wang-Nordman, Trond Warloe, Stefan Andersson-Engels, Roger Berg, Johan Moan, Qian Peng, Sune Svanberg

Author Affiliations +

Proceedings Volume 2387, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II; (1995) https://doi.org/10.1117/12.206834
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

Laser-induced fluorescence was used for the monitoring of the (delta) - amino levulinic acid (ALA)-induce protoporphyrin IX (PpIX) build-up in nonmelanoma malignant tumors of the skin and some cancers in the head and neck region. An optical-fiber based point monitoring system was utilized in the recording of fluorescence spectral at different time intervals after the administration of ALA. In the cases of skin tumors ALA was normally applied topically to the area. Only in one patient with an aggressive skin tumor ALA was administered intravenously. For the PpIX induction in the head and neck tumors the ALA was given orally. An example of a tumor fluorescence image is also presented.

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Katarina Svanberg M.D., Laudelina Pais Clemente, Manuel P. Clemente, Ingrid Wang-Nordman, Trond Warloe, Stefan Andersson-Engels, Roger Berg, Johan Moan, Qian Peng, and Sune Svanberg "Pharmacokinetic studies of δ-aminolevulinic-acid-induced protoporphyrin IX build-up in some malignant tumors", Proc. SPIE 2387, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, (12 April 1995); https://doi.org/10.1117/12.206834

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