Paper
1 March 1995 Photodynamic therapy with cationic photosensitizers
David Kessel, Kathryn W. Woodburn, Chi Kwong Chang, Barbara W. Henderson
Author Affiliations +
Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203370
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States
Abstract
We characterized sites of photodamage catalyzed by two cationic photosensitizers tetrabromo- rhodamine 123 (TBR), which is recognized by the multidrug transporter, and a monocationic porphyrin (MCP), which is not. The transporter is an outward transport system associated with examples of drug resistance. Irradiation of multidrug-resistant cells treated with TBR resulted in highly selective photodamage to the transporter site, while MCP catalyzed non- specific membrane damage to cells regardless of transporter expression.
© (1995) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
David Kessel, Kathryn W. Woodburn, Chi Kwong Chang, and Barbara W. Henderson "Photodynamic therapy with cationic photosensitizers", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203370
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KEYWORDS
Photodynamic therapy

Microchannel plates

Resistance

Rhodamine

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