Photodynamic therapy induced leukocyte adherence in normal subcutaneous, but not in tumor microvessels

Marc Dellian; Christoph Abels; Gerhard E.H. Kuhnle; Alwin E. Goetz

doi:10.1117/12.203393

1 March 1995 Photodynamic therapy induced leukocyte adherence in normal subcutaneous, but not in tumor microvessels

Marc Dellian, Christoph Abels, Gerhard E.H. Kuhnle, Alwin E. Goetz

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203393
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

Leukocyte mediated tissue damage is proposed to contribute to the tumoricidal effect of photodynamic therapy (PDT). To elucidate this hypothesis leukocyte-endothelium interaction and red blood cell velocity in the microvasculature of an amelanotic melanoma and normal tissue in a skin fold chamber preparation were investigated before and after PDT (5 mg/kg Photofrin^R; 630 nm; 10 or 100 J/cm²). One hour after PDT (10 and 100 J/cm²) the number of adhering leukocytes increased in subcutaneous but not in tumor microvessels. At this time red blood cell velocity remained unaltered in microvessels of subcutaneous tissue but decreased (10 J/cm²) and even ceased (100 J/cm²) in tumor microvessels. These results indicate that tumor destruction induced by PDT is not mediated by leukocyte-endothelium interaction.

Citation Download Citation

Marc Dellian, Christoph Abels, Gerhard E.H. Kuhnle, and Alwin E. Goetz "Photodynamic therapy induced leukocyte adherence in normal subcutaneous, but not in tumor microvessels", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203393

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