Ultrastructural evaluation of CaD2 mouse mammary carcinoma after photodynamic therapy with meso-tetra(hydroxyphenyl)porphyrin (m-THPP) or its corresponding chlorin (m-THPC)

Qian Peng; Johan Moan; Jahn M. Nesland

doi:10.1117/12.200905

1 February 1995 Ultrastructural evaluation of CaD2 mouse mammary carcinoma after photodynamic therapy with meso-tetra(hydroxyphenyl)porphyrin (m-THPP) or its corresponding chlorin (m-THPC)

Qian Peng, Johan Moan, Jahn M. Nesland

Author Affiliations +

Proceedings Volume 2329, Optical and Imaging Techniques in Biomedicine; (1995) https://doi.org/10.1117/12.200905
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

The ultrastructural changes that occurred in CaD2 mouse mammary carcinoma at 1, 24, and 96 h after photodynamic therapy (PDT) with meso-tetra(m-hydroxyphenyl)porphyrin (m- THPP, 5 mg/kg b.w.) or its corresponding chlorin (m-THPC, 1 mg/kg b.w.) were investigated. The destruction of the tumors occurred at a faster rate and was more severe by m-THPC-PDT than m-THPP-PDT, although the dose of m-THPC used was 5 times lower than that of m-THPP. The ultrastructral alterations of the tumors after PDT with m-THPP or m-THPC were qualitatively similar: direct damage to both microvasculature and neoplastic cells of the tumors.

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Qian Peng, Johan Moan, and Jahn M. Nesland "Ultrastructural evaluation of CaD2 mouse mammary carcinoma after photodynamic therapy with meso-tetra(hydroxyphenyl)porphyrin (m-THPP) or its corresponding chlorin (m-THPC)", Proc. SPIE 2329, Optical and Imaging Techniques in Biomedicine, (1 February 1995); https://doi.org/10.1117/12.200905

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