Comparative analysis of different phthalocyanine photosensitizers for experimental PDT of cancer

Maria G. Galpern; Irina Novozhilova; Galina Sokolova; Georgy N. Vorozhtsov; Natalia N. Zharkova; Dmitrij N. Kozlov; Victor V. Sokolov; Garry M. Sukhin

doi:10.1117/12.199154

12 January 1995 Comparative analysis of different phthalocyanine photosensitizers for experimental PDT of cancer

Maria G. Galpern, Irina Novozhilova, Galina Sokolova, Georgy N. Vorozhtsov, Natalia N. Zharkova, Dmitrij N. Kozlov, Victor V. Sokolov, Garry M. Sukhin

Author Affiliations +

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199154
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

Preliminary biological screening has resulted in data about the considerable difference in photodynamic activity of sulfuric acids of aluminum phthalocyanine and their different salts have been obtained. The photosensitizers have been introduced intravenously in laboratory male mice 24 hours before direct laser irradiation of the liver area through the front abdominal side. Seven-day Erlich carcinomas with a diameter of 0.5 cm transplanted hypodermically to the mice have been used as an experimental tumor model. Obtained data of preliminary biological screening on photodynamic activity and tumor selectivity of different photosensitizers has been confirmed by direct experiments on the PDT experimental tumor in mice with the use of a laser system on the basis of yttrium aluminate with the wavelength 670 nm. Preparations have been introduced as a solution 2 mg/ml intravenous with a dose 10 mg/kg 48 hours before irradiation with the laser. Irradiation dose was 90 J with a spot diameter of 1 cm. Efficiency of anti-tumor PDT has been estimated by sight and with morphological study of the material.

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Maria G. Galpern, Irina Novozhilova, Galina Sokolova, Georgy N. Vorozhtsov, Natalia N. Zharkova, Dmitrij N. Kozlov, Victor V. Sokolov, and Garry M. Sukhin "Comparative analysis of different phthalocyanine photosensitizers for experimental PDT of cancer", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199154

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KEYWORDS

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Photodynamic therapy

Cancer

Sodium

Liver

Luminescence

Aluminum

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