Estimation of risks by chemicals produced during laser pyrolysis of tissues

Lothar W. Weber; Martin Spleiss

doi:10.1117/12.199241

18 January 1995 Estimation of risks by chemicals produced during laser pyrolysis of tissues

Lothar W. Weber, Martin Spleiss

Proceedings Volume 2323, Laser Interaction with Hard and Soft Tissue II; (1995) https://doi.org/10.1117/12.199241
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

Use of laser systems in minimal invasive surgery results in formation of laser aerosol with volatile organic compounds of possible health risk. By use of currently identified chemical substances an overview on possibly associated risks to human health is given. The class of the different identified alkylnitriles seem to be a laser specific toxicological problem. Other groups of chemicals belong to the Maillard reaction type, the fatty acid pyrolysis type, or even the thermally activated chemolysis. In relation to the available different threshold limit values the possible exposure ranges of identified substances are discussed. A rough estimation results in an exposure range of less than 1/100 for almost all substances with given human threshold limit values without regard of possible interactions. For most identified alkylnitriles, alkenes, and heterocycles no threshold limit values are given for lack of, until now, practical purposes. Pyrolysis of anaesthetized organs with isoflurane gave no hints for additional pyrolysis products by fragment interactions with resulting VOCs. Measurements of pyrolysis gases resulted in detection of small amounts of NO additionally with NO₂ formation at plasma status.

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Lothar W. Weber and Martin Spleiss "Estimation of risks by chemicals produced during laser pyrolysis of tissues", Proc. SPIE 2323, Laser Interaction with Hard and Soft Tissue II, (18 January 1995); https://doi.org/10.1117/12.199241

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