Biosensor technology for the detection of illegal drugs I: objectives, preparatory work, and drug enrichment

Reinhold Hilpert; Florian Binder; Michael Grol; Klaus Hallermayer; Hans-Peter Josel; Christian Klein; Josef Maier; Helmut Oberpriller; Josef Ritter; Frieder W. Scheller

doi:10.1117/12.189162

6 October 1994 Biosensor technology for the detection of illegal drugs I: objectives, preparatory work, and drug enrichment

Reinhold Hilpert, Florian Binder, Michael Grol, Klaus Hallermayer, Hans-Peter Josel, Christian Klein, Josef Maier, Helmut Oberpriller, Josef Ritter, Frieder W. Scheller

Author Affiliations +

Proceedings Volume 2276, Cargo Inspection Technologies; (1994) https://doi.org/10.1117/12.189162
Event: SPIE's 1994 International Symposium on Optics, Imaging, and Instrumentation, 1994, San Diego, CA, United States

Abstract

In a joint project of Deutsche Aerospace, Boehringer Mannheim and the University of Potsdam portable devices for the detection of illegal drugs, based on biosensor technology, are being developed. The concept enrichment of the drug from the gas phase and detection by immunological means. This publication covers the description of our objectives, preparatory work and results concerning enrichment of drugs from the gas phase. Vapor pressures of cocaine and cannabinoids have been determined. A test gas generator has been constructed which allows for reproducible preparation of cocaine concentrations between 2 ng/l and 2 pg/l. Coupling of a thermodesorption unit with GC/MS has been established for reference analysis. As another analytical tool, an ELISA with a lower detection limit of about 0,5 pg cocaine/assay has been developed. Applying fleece-type adsorbers, enrichment factors for cocaine in the range of 10⁵ have been realized. No significant interference was found with potentially disturbing substances.

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Reinhold Hilpert, Florian Binder, Michael Grol, Klaus Hallermayer, Hans-Peter Josel, Christian Klein, Josef Maier, Helmut Oberpriller, Josef Ritter, and Frieder W. Scheller "Biosensor technology for the detection of illegal drugs I: objectives, preparatory work, and drug enrichment", Proc. SPIE 2276, Cargo Inspection Technologies, (6 October 1994); https://doi.org/10.1117/12.189162

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