Depth dependent laser Doppler perfusion measurements: theory and instrumentation

Marco H. Koelink; Frits F. M. de Mul; Jan Greve; Reindert Graaff; A. C. M. Dassel; Jan G. Aarnoudse

doi:10.1117/12.57352

1 May 1991 Depth dependent laser Doppler perfusion measurements: theory and instrumentation

Marco H. Koelink, Frits F. M. de Mul, Jan Greve, Reindert Graaff, A. C. M. Dassel, Jan G. Aarnoudse

Proceedings Volume 1403, Laser Applications in Life Sciences; (1991) https://doi.org/10.1117/12.57352
Event: Laser Applications in Life Sciences, 1990, Moscow, Russian Federation

Abstract

Laser Doppler velocimetry provides a method for non invasive measurements of the perfusion of tissue. Therefore the tissue is illuminated with a monochromatic light source and back scattered light from the tissue is collected at a detector at an adjacent site. Some of the back scattered photons have had interaction with moving red blood cells and are frequency shifted. Due to interference of frequency shifted and non-frequency shifted photons, the intensity at the detector fluctuates. These fluctuations provide the information from which a rate for the perfusion can be derived. ' Recently, the possibility of performing depth dependent measurements on the skin by3 4vrying the position an size of the sample volume has been investigated. In this paper we demonstrate that there are at least three different ways to vary the position and size of the probe volume: 1) Using a different wavelength of the laser. 2) Varying the distance from the laser to the detector. 3) Varying the angle of penetration of the laser light into the tissue.

Citation Download Citation

Marco H. Koelink, Frits F. M. de Mul, Jan Greve, Reindert Graaff, A. C. M. Dassel, and Jan G. Aarnoudse "Depth dependent laser Doppler perfusion measurements: theory and instrumentation", Proc. SPIE 1403, Laser Applications in Life Sciences, (1 May 1991); https://doi.org/10.1117/12.57352

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