Planar waveguide optical immunosensors

Steven J. Choquette; Laurie E. Locascio-Brown; Richard A. Durst

doi:10.1117/12.24803

1 March 1991 Planar waveguide optical immunosensors

Steven J. Choquette, Laurie E. Locascio-Brown, Richard A. Durst

Proceedings Volume 1368, Chemical, Biochemical, and Environmental Fiber Sensors II; (1991) https://doi.org/10.1117/12.24803
Event: SPIE Microelectronic Interconnect and Integrated Processing Symposium, 1990, San Jose, United States

Abstract

Monoclonal antibodies were covalently bonded to the surfaces of planar waveguides to confer immunoreacth''ity. Silver-ion diffused waveguides were used to measure theophylline concentrations in a fluorescence immunoassay and silicon nitride waveguides were used to detect theophylline in an absorbance-based immunoassay. Liposomes were employed in both assays as the optically detectable label in a competitive reaction to monitor antigen-antibody complexation. Regeneration of the active antibody site will be discussed.

Citation Download Citation

Steven J. Choquette, Laurie E. Locascio-Brown, and Richard A. Durst "Planar waveguide optical immunosensors", Proc. SPIE 1368, Chemical, Biochemical, and Environmental Fiber Sensors II, (1 March 1991); https://doi.org/10.1117/12.24803

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