Label-free super-resolution imaging using patchy microspheres in various mediums

Pengxin Zou; Chu Xu; Zengbo Wang; Sorin Melinte; Ran Ye

doi:10.1117/12.3023803

18 June 2024 Label-free super-resolution imaging using patchy microspheres in various mediums

Pengxin Zou, Chu Xu, Zengbo Wang, Sorin Melinte, Ran Ye

Proceedings Volume 12996, Unconventional Optical Imaging IV; 129960J (2024) https://doi.org/10.1117/12.3023803
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

The diffraction limit is a fundamental barrier in optical microscopy, restricting the smallest resolvable feature size of a microscopic imaging system. Microsphere-assisted super-resolution microscopy has emerged as a promising approach for overcoming this limit. This technique offers several advantages, including no need of fluorescent dyes, easy operation under white light illumination, and good compatibility with commercial optical microscopes. Various strategies have been proposed to enhance the imaging performance of microspheres. Recently, patchy microspheres were found to exhibit super-resolution capabilities in air with an enhanced imaging contrast. In this work, we studied the super-resolution imaging performance of patchy microspheres fully immersed in liquid. Furthermore, we demonstrated the formation of photonic hooks from patchy microspheres within a liquid environment. The findings of this study will extent the application of patchy microspheres from air to liquid immersion mode, opening up new possibilities for super-resolution imaging in liquid environment with patchy microspheres.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Pengxin Zou, Chu Xu, Zengbo Wang, Sorin Melinte, and Ran Ye "Label-free super-resolution imaging using patchy microspheres in various mediums", Proc. SPIE 12996, Unconventional Optical Imaging IV, 129960J (18 June 2024); https://doi.org/10.1117/12.3023803

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