High-sensitivity efficacy evaluation methods for vascular-targeted photodynamic therapy of port-wine stains

Junbo Xi; Li Lin; Haixia Qiu; Buhong Li

doi:10.1117/12.3015908

29 December 2023 High-sensitivity efficacy evaluation methods for vascular-targeted photodynamic therapy of port-wine stains

Junbo Xi, Li Lin, Haixia Qiu, Buhong Li

Author Affiliations +

Proceedings Volume 12975, 6th Optics Young Scientist Summit (OYSS 2023); 129750Z (2023) https://doi.org/10.1117/12.3015908
Event: 6th Optics Young Scientist Summit, 2023, Changsha, China

Abstract

Vascular-targeted photodynamic therapy (V-PDT) has become an important therapeutic method for blood vessel-related diseases such as Port-Wine Stains (PWSs). To achieve more precise V-PDT, quantitative evaluation of V-PDT efficiency appears to be an essential prerequisite. In previous study, methods of Euclidean distance and two-dimensional correlation coefficient, which were calculated based on PWS lesion images, had been employed to evaluate the efficacy of V-PDT. However, results of the mentioned methods show little difference for different V-PDT efficiency, which indicates a limited sensitivity leading to difficulties in V-PDT efficacy evaluation. In this work, evaluation methods with higher sensitivity, including pixel count change, average gray value change, and entropy change which were analyzed based on lesion images before and after V-PDT, were developed for V-PDT efficiency evaluation on PWS. These evaluation methods reveal V-PDT effect from aspects of lesion area, skin color, and skin texture. In addition, relative difference rates of all methods were analyzed for sensitivity comparison. The results indicate that changes of pixel number, average grayscale value, and entropy well reflect differences in V-PDT efficacy and exhibit much higher sensitivity in comparison with that of Euclidean distance and two-dimensional correlation coefficient, confirming themselves a promising quantitative evaluation method for V-PDT efficacy.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Junbo Xi, Li Lin, Haixia Qiu, and Buhong Li "High-sensitivity efficacy evaluation methods for vascular-targeted photodynamic therapy of port-wine stains", Proc. SPIE 12975, 6th Optics Young Scientist Summit (OYSS 2023), 129750Z (29 December 2023); https://doi.org/10.1117/12.3015908

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KEYWORDS

Correlation coefficients

Skin

Histograms

Photodynamic therapy

Image processing

Light sources and illumination

Reflection

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