Precision radioligand therapy calls for patient dosimetry, which in turn requires the knowledge of time integrated activity curves for various tissues of interest, often acquired through post therapy imaging. A number of imaging methods have been proposed, with considerations of both dosimetric accuracy and the practicality of the method. Clinical studies on patients, as the more traditional way of evaluating these methods, are faced with challenges from: (1) the lack of ground truth and (2) the burden of performing the clinical studies. A Monte Carlo simulation based approach, as is proposed in this work, would address the challenges and provide fast and reliable ways to assess different imaging method. The presented work demonstrates the potential of the proposed simulation based approach in the the design of the post radioligand therapy imaging methods for patient dosimetry purposes.
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