Gold nanoparticles for enhanced delivery of chemotherapy

Idan Katzir; Yoray Sharon; Tamar Sadan; Menachem Motiei; Rachela Popovtzer

doi:10.1117/12.3005422

13 March 2024 Gold nanoparticles for enhanced delivery of chemotherapy

Idan Katzir, Yoray Sharon, Tamar Sadan, Menachem Motiei, Rachela Popovtzer

Proceedings Volume 12858, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI; 128580C (2024) https://doi.org/10.1117/12.3005422
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Chemotherapy is the gold standard for cancer treatment. However, the specific and safe delivery of chemotherapies to cancer cells remains a great challenge. Gold nanoparticles (GNPs) offer a promising solution as carriers for chemotherapy due to their biocompatibility and distinctive physicochemical properties that facilitate precise drug binding and enhanced tumor penetration through the enhanced permeability and retention effect. Here, we have designed GNPs bound to chemotherapies together with glucose coating and studied their cancer cell killing efficacy in a head and neck squamous cell carcinoma cell line. We found that the GNPs bound to chemotherapy had a higher cancer cell killing efficacy as compared to controls, as well as a bystander effect. This GNP-based platform holds promise, for advancing chemotherapy-based cancer treatments.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Idan Katzir, Yoray Sharon, Tamar Sadan, Menachem Motiei, and Rachela Popovtzer "Gold nanoparticles for enhanced delivery of chemotherapy", Proc. SPIE 12858, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI, 128580C (13 March 2024); https://doi.org/10.1117/12.3005422

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