Nanobomb-assisted layer-specific optical coherence elastography

Maryam Hatami; Dmitry Nevozhay; Manmohan Singh; Alexander W. Schill; Paul Boerner; Konstantin V. Sokolov; Kirill V. Larin

doi:10.1117/12.3003277

12 March 2024 Nanobomb-assisted layer-specific optical coherence elastography

Maryam Hatami, Dmitry Nevozhay, Manmohan Singh, Alexander W. Schill, Paul Boerner, Konstantin V. Sokolov, Kirill V. Larin

Author Affiliations +

Proceedings Volume 12844, Optical Elastography and Tissue Biomechanics XI; 1284407 (2024) https://doi.org/10.1117/12.3003277
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Liquid to gas phase transition of dye-loaded PFC nanodroplets (nanobombs, NBs) can be facilitated by the optical absorption of energy of laser pulse. Activation of NBs with laser pulse can produce highly localized longitudinal shear waves (LSW). The advent of LSW elastography has enhanced the ability to measure depth-dependent tissue elasticity. Highly localized NB-induced LSWs propagate through the tissue depth and can discriminate the tissue elasticity gradients along the depth. In this study, we explore the capability of the NB-induced LSWs in discriminating the elasticity properties of multilayered tissue-mimicking phantoms. The NB present in the middle layer of the test phantoms produced LSWs upon the pulse laser excitation, which can provide elasticity information in the sample depth where the NBs are located and the elasticity of layers of the sample on top and bottom of the NB layer.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Maryam Hatami, Dmitry Nevozhay, Manmohan Singh, Alexander W. Schill, Paul Boerner, Konstantin V. Sokolov, and Kirill V. Larin "Nanobomb-assisted layer-specific optical coherence elastography", Proc. SPIE 12844, Optical Elastography and Tissue Biomechanics XI, 1284407 (12 March 2024); https://doi.org/10.1117/12.3003277

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