The role of brown adipose tissue in the thermogenesis and the treatment of obesity

Jingwei Wei

doi:10.1117/12.2692771

7 September 2023 The role of brown adipose tissue in the thermogenesis and the treatment of obesity

Jingwei Wei

Proceedings Volume 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023); 1278927 (2023) https://doi.org/10.1117/12.2692771
Event: International Conference on Modern Medicine and Global Health (ICMMGH 2023), 2023, Oxford, United Kingdom

Abstract

Due to the complex pathogenesis of obesity and the increasing number of obese patients, researchers have worked on how to deal with obesity. Researchers have found that brown adipose tissue (BAT) has an impact on the treatment of obese patients. The review introduces basic knowledge related to BAT characteristics, cold exposure to activate BAT, and the activation pathway of BAT, including the UCP1-dependent signaling pathway and the UCP1-independent signaling pathway, in order to investigate the novel technology on treating obesity by focusing on BAT. Moreover, the review summarizes the novel therapies to combat obesity through BAT. The therapies incorporate BAT transplantation, transformation of white adipose tissue, and artificial means to activate BAT by either using pharmaceutical ways or controlling the expression of genes. Through the multiple ways to increase the BAT mass in the human body, the results show that obesity can be partially alleviated. However, future studies still need to reveal the integrated mechanism of treating obesity with changing BAT mass.

Citation Download Citation

Jingwei Wei "The role of brown adipose tissue in the thermogenesis and the treatment of obesity", Proc. SPIE 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023), 1278927 (7 September 2023); https://doi.org/10.1117/12.2692771

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KEYWORDS

Adipose tissue

Mitochondria

Mode conditioning cables

Acquisition tracking and pointing

Calcium

Therapeutics

Transplantation

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