Application of SERS method for detection of methotrexate molecules in human plasma

Elizaveta Demishkevich; Andrey Zyubin; Vladimir Rafalskiy; Svetlana Doktorova; Anna Kundalevich; Alexander Zozulya; Denis Evtifeev; Ilya Samusev

doi:10.1117/12.2689134

28 November 2023 Application of SERS method for detection of methotrexate molecules in human plasma

Elizaveta Demishkevich, Andrey Zyubin, Vladimir Rafalskiy, Svetlana Doktorova, Anna Kundalevich, Alexander Zozulya, Denis Evtifeev, Ilya Samusev

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Proceedings Volume 12774, Plasmonics VII; 127740C (2023) https://doi.org/10.1117/12.2689134
Event: SPIE/COS Photonics Asia, 2023, Beijing, China

Abstract

This study demonstrates the possibility of the surface enhanced Raman spectroscopy (SERS) method to determine concentrations of methotrexate (MTX) in human plasma. This method makes it possible to detect low concentrations of methotrexate in biological samples with relatively inexpensive portable equipment. The SERS signal may be greatly enhanced using nanostructured plasmonic materials which will make this method highly sensitive, selective and productive. The use of SERS to perform a therapeutic drug monitoring procedure is a promising method because of its extreme sensitivity, specificity and speed of analysis.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Elizaveta Demishkevich, Andrey Zyubin, Vladimir Rafalskiy, Svetlana Doktorova, Anna Kundalevich, Alexander Zozulya, Denis Evtifeev, and Ilya Samusev "Application of SERS method for detection of methotrexate molecules in human plasma", Proc. SPIE 12774, Plasmonics VII, 127740C (28 November 2023); https://doi.org/10.1117/12.2689134

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KEYWORDS

Plasma

Surface enhanced Raman spectroscopy

Nanoparticles

Biological samples

Molecules

Raman spectroscopy

Vibration

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