A portable surface-enhanced Raman spectroscopy platform for biofluid analysis

Sergio Quintero; Maria Relvas; Alexandra Teixeira; Sara Abalde-Cela; Lorena Diéguez

doi:10.1117/12.2686892

11 August 2023 A portable surface-enhanced Raman spectroscopy platform for biofluid analysis

Sergio Quintero, Maria Relvas, Alexandra Teixeira, Sara Abalde-Cela, Lorena Diéguez

Proceedings Volume 12627, Translational Biophotonics: Diagnostics and Therapeutics III; 1262736 (2023) https://doi.org/10.1117/12.2686892
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

Portable Raman and surface-enhanced Raman scattering spectroscopy (SERS) systems have gained great interest in biomedical science, especially when combined with microfluidics, since it allows the application of this sensitive technology in low-resource settings, providing fast results at a low-cost level. Moreover, these portable systems are also more versatile and user-friendly than microscope-based approaches. In this work, we propose the design of a complete portable SERS equipment for the analysis of biofluids. The system was optimized and tested using the Raman reporter 4- mercaptobenzoic acid (4-MBA) and, as a proof of concept, we performed a calibration curve using another Raman reporter: 1-naphtalenethiol (1NAT), being able to detect concentrations as lower as 2*10^-4 M. The results presented here show the potential of the system to detect different and relevant biomarkers, and even be part of more complex systems like Point-of-care or Lab-on-a-chip devices.

Citation Download Citation

Sergio Quintero, Maria Relvas, Alexandra Teixeira, Sara Abalde-Cela, and Lorena Diéguez "A portable surface-enhanced Raman spectroscopy platform for biofluid analysis", Proc. SPIE 12627, Translational Biophotonics: Diagnostics and Therapeutics III, 1262736 (11 August 2023); https://doi.org/10.1117/12.2686892

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