7 April 2023Multifocal optical metasurfaces for cellular-resolution optical coherence tomography for rapid slide-free histology of human brain and skin samples
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Cellular resolution of optical coherence tomography (OCT) is vital to achieving precise diagnosis by offering high-quality images of slide-free histology. Currently, the common solution is to apply dynamic focusing to axially translate the focus through the region of interest with a high numerical aperture (N.A.) objective, followed by Z-stacking to rebuild a high-resolution 3D volume. To accelerate the imaging acquisition, this work developed optical metasurface plates to generate multiple foci along the axial direction. Two-/three-/seven-foci had been testified with bead phantom using a scanning OCT. Human skin and human brain samples were imaged with cellular resolution.
Jingjing Zhao,Aidan Van Vleck,Yonatan Winetraub,Lin Du,Yong Han,Sumaira Aasi,Kavita Yang Sarin, andAdam de la Zerda
"Multifocal optical metasurfaces for cellular-resolution optical coherence tomography for rapid slide-free histology of human brain and skin samples", Proc. SPIE 12471, Medical Imaging 2023: Digital and Computational Pathology, 124711U (7 April 2023); https://doi.org/10.1117/12.2654983
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Jingjing Zhao, Aidan Van Vleck, Yonatan Winetraub, Lin Du, Yong Han, Sumaira Aasi, Kavita Yang Sarin, Adam de la Zerda, "Multifocal optical metasurfaces for cellular-resolution optical coherence tomography for rapid slide-free histology of human brain and skin samples," Proc. SPIE 12471, Medical Imaging 2023: Digital and Computational Pathology, 124711U (7 April 2023); https://doi.org/10.1117/12.2654983