This talk will present our recent results on photobiomodulation (PBM) in multiple cell types and models in vitro and in a mouse model in vivo. Different wavelengths (e.g., 650 nm, 808 nm, 1064 nm) and doses were employed and post-PBM changes in cells and animals were assessed in vitro, ex vivo and in vivo using fluorescence microscopy with fluorescent probes and label-free nonlinear optical imaging. The obtained imaging data, along with results of other assays, allowed for revealing PBM action and mechanisms. The talk will conclude with a discussion on application of red and NIR PBM to treat some diseases.
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