Comparing methodologies for assessing autoregulation in a pediatric swine model using non-invasive optical measurements

Bryce Carr; Kichang Lee; Ekaterina Creed; Dibbyan Mazumder; Behzad Khajavi; Kitae Jung; Michael G. Silverman; Stefan Carp

doi:10.1117/12.2651036

17 March 2023 Comparing methodologies for assessing autoregulation in a pediatric swine model using non-invasive optical measurements

Bryce Carr, Kichang Lee, Ekaterina Creed, Dibbyan Mazumder, Behzad Khajavi, Kitae Jung, Michael G. Silverman, Stefan Carp

Author Affiliations +

Proceedings Volume 12364, Clinical and Translational Neurophotonics 2023; 123640M (2023) https://doi.org/10.1117/12.2651036
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Cerebral autoregulation (CA), the brain’s ability to regulate perfusion independently of blood pressure, can be assessed by evaluating the degree of correlation between cerebral blood flow (CBF) and mean arterial pressure. Non-invasive, optical measurements of brain hemodynamics using DCS/NIRS can be used to assess CA and show agreement with invasive metrics (laser doppler perfusion and intracranial pressure) in a pediatric swine model of cardiac arrest. Wavelet based coherence methods of assessing autoregulation are a useful alternative to correlation based methods.

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Bryce Carr, Kichang Lee, Ekaterina Creed, Dibbyan Mazumder, Behzad Khajavi, Kitae Jung, Michael G. Silverman, and Stefan Carp "Comparing methodologies for assessing autoregulation in a pediatric swine model using non-invasive optical measurements", Proc. SPIE 12364, Clinical and Translational Neurophotonics 2023, 123640M (17 March 2023); https://doi.org/10.1117/12.2651036

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