Diffuse optical spectroscopies for detecting hemometabolic stress in pediatric sickle cell disease

Rowan O. Brothers; Katherine Turrentine; Mariam Akbar; Sydney Triplett; Robert C. Brown; Erin Buckley

doi:10.1117/12.2651295

17 March 2023 Diffuse optical spectroscopies for detecting hemometabolic stress in pediatric sickle cell disease

Rowan O. Brothers, Katherine Turrentine, Mariam Akbar, Sydney Triplett, Robert C. Brown, Erin Buckley

Proceedings Volume 12364, Clinical and Translational Neurophotonics 2023; 123640L (2023) https://doi.org/10.1117/12.2651295
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

In children with sickle cell disease, there is a clinical need for non-invasive quantification of the degree of hemometabolic stress in these patients to mitigate risk of stroke. Frequency-domain near-infrared spectroscopy (FDNIRS) and diffuse correlation spectroscopy (DCS) measures of regional oxygen extraction fraction, cerebral blood flow, and cerebral metabolic rate of oxygen have potential to provide markers of cerebral metabolic stress. In this study, we characterize the intra-subject and inter-operator repeatability of these measures, and we correlate DCS measures of cerebral blood flow index against both arterial spin-labeled MRI and transcranial Doppler ultrasound in a cohort of pediatric SCD patients.

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Rowan O. Brothers, Katherine Turrentine, Mariam Akbar, Sydney Triplett, Robert C. Brown, and Erin Buckley "Diffuse optical spectroscopies for detecting hemometabolic stress in pediatric sickle cell disease", Proc. SPIE 12364, Clinical and Translational Neurophotonics 2023, 123640L (17 March 2023); https://doi.org/10.1117/12.2651295

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KEYWORDS

Diffuse optical spectroscopy

Oxygen

Cerebral blood flow

Magnetic resonance imaging

Near infrared spectroscopy

Doppler effect

Mode conditioning cables

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