Diffuse correlation spectroscopy measured cerebral blood flow is associated with outcome after subarachnoid hemorrhage

Eashani Sathialingam; Kyle Cowdrick; Tara Urner; Shasha Bai; Feras Akbik; Owen Samuels; Prem Kandiah; Ofer Sadan; Erin Buckley

doi:10.1117/12.2649170

17 March 2023 Diffuse correlation spectroscopy measured cerebral blood flow is associated with outcome after subarachnoid hemorrhage

Eashani Sathialingam, Kyle Cowdrick, Tara Urner, Shasha Bai, Feras Akbik, Owen Samuels, Prem Kandiah, Ofer Sadan, Erin Buckley

Author Affiliations +

Proceedings Volume 12364, Clinical and Translational Neurophotonics 2023; 123640K (2023) https://doi.org/10.1117/12.2649170
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We use diffuse correlation spectroscopy (DCS) to measure changes in microvascular blood flow in subarachnoid hemorrhage patients treated with intrathecal nicardipine. Our results suggest that IT nicardipine achieves the desired effect of microvascular vasodilation in the majority of patients. The CBF response plateaus by day 3, indicative of steady state of drug concentration in the brain. Interestingly, those patients whose microvascular cerebral blood flow did not respond were the ones who went on to develop worse outcome in the form of a secondary stroke.

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Eashani Sathialingam, Kyle Cowdrick, Tara Urner, Shasha Bai, Feras Akbik, Owen Samuels, Prem Kandiah, Ofer Sadan, and Erin Buckley "Diffuse correlation spectroscopy measured cerebral blood flow is associated with outcome after subarachnoid hemorrhage", Proc. SPIE 12364, Clinical and Translational Neurophotonics 2023, 123640K (17 March 2023); https://doi.org/10.1117/12.2649170

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