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17 March 2023 Measuring skin penetration under in-use conditions
Yousuf Mohammed, Krishna Telaprolu, Jonathan Wei, David Liu, Michael Roberts
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Proceedings Volume 12357, Visualizing and Quantifying Drug Distribution in Tissue VII; 123570C (2023) https://doi.org/10.1117/12.2648108
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Understanding skin drug diffusion under in use conditions is a prerequisite to building accurate and predictive mathematical models. Non-invasive microscopic techniques, combined with use of an epidermal model that retains viability without destroying and disrupting the biological, metabolic, chemical and enzymatic properties of the skin can enable in vitro characterisation of molecular diffusion without the need for in vivo experiments. We studied drug diffusion in the presence and absence of transport inhibitors, to highlight the significance of the right in vitro models, while making key observations of diffusion kinetics and cellular transport.
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Yousuf Mohammed, Krishna Telaprolu, Jonathan Wei, David Liu, and Michael Roberts "Measuring skin penetration under in-use conditions", Proc. SPIE 12357, Visualizing and Quantifying Drug Distribution in Tissue VII, 123570C (17 March 2023); https://doi.org/10.1117/12.2648108
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KEYWORDS
Skin
Diffusion
Mathematical modeling
Molecules
In vivo imaging
Luminescence
MATLAB
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