Surface-enhanced Raman spectroscopy of peptides

Robin L. Garrell; Tonya M. Herne; Angela M. Ahern; Eve L. Sullenberger

doi:10.1117/12.17604

1 July 1990 Surface-enhanced Raman spectroscopy of peptides

Robin L. Garrell, Tonya M. Herne, Angela M. Ahern, Eve L. Sullenberger

Proceedings Volume 1201, Optical Fibers in Medicine V; (1990) https://doi.org/10.1117/12.17604
Event: OE/LASE '90, 1990, Los Angeles, CA, United States

Abstract

Surface-enhanced Raman (SER) spectroscopy has been used to probe the adsorption, surface interactions, and orientations of peptides on metal surfaces. Amino acids in homodipeptides give SER spectra with unique features that can be used to characterize the surface interactions of specific functional groups in more complicated peptides. In heterodipeptides, there is a hierarchy of functional group-surface interactions that prescribe their orientation and conformation on metal surfaces. By establishing this hierarchy, it is now possible to predict the interactions that occur between larger peptides and surfaces. Furthermore, the observed trends suggest that it should be possible to control these interactions by varying the solution pH, the charge on the surface, and other parameters of the measurement in order to adsorb species selectively from mixtures of peptides in solution. Potential biomedical applications of this technique will be described.

Citation Download Citation

Robin L. Garrell, Tonya M. Herne, Angela M. Ahern, and Eve L. Sullenberger "Surface-enhanced Raman spectroscopy of peptides", Proc. SPIE 1201, Optical Fibers in Medicine V, (1 July 1990); https://doi.org/10.1117/12.17604

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available