Some attempts for improvement of balloon laserthermia

Koichi Futatsuki; Koji Saifuku; Kunio Yamamoto; Nobuyuki Takeuchi; Yuzoh Kanda; Tositaka Uehara; Yoshio Sekiguchi

doi:10.1117/12.17598

1 July 1990 Some attempts for improvement of balloon laserthermia

Koichi Futatsuki, Koji Saifuku, Kunio Yamamoto, Nobuyuki Takeuchi, Yuzoh Kanda, Tositaka Uehara, Yoshio Sekiguchi

Proceedings Volume 1201, Optical Fibers in Medicine V; (1990) https://doi.org/10.1117/12.17598
Event: OE/LASE '90, 1990, Los Angeles, CA, United States

Abstract

We investigated the use of a new Nd:YAG laser irradiation method, 'balloon laserthermia' I involving use of a balloon filled with a light diffusing substance attached to the end of a quartz fiber. This balloon laserthermia technique, using a 3cm diameter balloon containing 0.25% Intralipid solution, was tested on a Meth-A sarcoma in Balb-C mice. A 20 minute irradiation at 20 watts resulted in the following necrosis rates: control group -4%; 40.0-40.5°C. 35%; 42.5-62%; 50.0 -50.5°C. - 97%. When the balloon size was reduced from 3 to 2cm, the optimum values for hypertherinia were a 0.5% Intralipid solution density and a laser power output of 10 watts. As previous use of balloon laserthermia has generally involved use of quartz fibers with a standard 8° angle of light emission, these experiments included trials of a fiber with a 40°light emission angle, along with various combinations of solution densities and laser output conditions. When used with 0.25% Intralipid I the wide-angle fiber provided a power density distribution around the balloon equivalent to that of the standard fiber, but with only half the laser output for hyperthermia, about 10 watts.

Citation Download Citation

Koichi Futatsuki, Koji Saifuku, Kunio Yamamoto, Nobuyuki Takeuchi, Yuzoh Kanda, Tositaka Uehara, and Yoshio Sekiguchi "Some attempts for improvement of balloon laserthermia", Proc. SPIE 1201, Optical Fibers in Medicine V, (1 July 1990); https://doi.org/10.1117/12.17598

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