Determination of the binary diffusion coefficient of an iodine-glycerol preparation (Lugol) in the dentin of a human tooth

A. A. Selifonov; A. M. Zakharevich; V. V. Tuchin

doi:10.1117/12.2591155

4 May 2021 Determination of the binary diffusion coefficient of an iodine-glycerol preparation (Lugol) in the dentin of a human tooth

A. A. Selifonov, A. M. Zakharevich, V. V. Tuchin

Author Affiliations +

Proceedings Volume 11845, Saratov Fall Meeting 2020: Optical and Nanotechnologies for Biology and Medicine; 118450V (2021) https://doi.org/10.1117/12.2591155
Event: Saratov Fall Meeting 2020, 2020, Saratov, Russian Federation

Abstract

Lugol as an antiseptic dye based on iodine and glycerol is widely used in clinical dentistry to identify areas of tooth demineralization and to detect initial caries. In this work, the kinetic parameters of Lugol (aqueous solution of potassium iodide (0.02 w/w) and glycerol (0.94 w/w)) diffusion in the dentin of a human tooth are determined. A modified Fick's second law, free diffusion model, and diffuse reflectance spectroscopy were used to determine the effective Lugol diffusion coefficient (binary diffusion coefficients of tissue water and iodine/glycerol complex) in the dentin of a human tooth. The quantitative parameters of Lugol's penetration into the dentin of a human tooth and a change in its optical properties should be taken into account when drawing up clinical protocols for the treatment of dental diseases using phototherapy, physiotherapy, photodynamic therapy, laser treatment, etc.

Citation Download Citation

A. A. Selifonov, A. M. Zakharevich, and V. V. Tuchin "Determination of the binary diffusion coefficient of an iodine-glycerol preparation (Lugol) in the dentin of a human tooth", Proc. SPIE 11845, Saratov Fall Meeting 2020: Optical and Nanotechnologies for Biology and Medicine, 118450V (4 May 2021); https://doi.org/10.1117/12.2591155

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