Cholesterol-enriched erythrocyte-derived optical nanoparticles for NIR fluorescence imaging of intraperitoneal ovarian tumors in mice

Chi-Hua Lee; Jack C. Tang; Raviraj Vankayala; Jenny T. Mac; Taylor Hanley; Bahman Anvari

doi:10.1117/12.2582797

16 March 2021 Cholesterol-enriched erythrocyte-derived optical nanoparticles for NIR fluorescence imaging of intraperitoneal ovarian tumors in mice

Chi-Hua Lee, Jack C. Tang, Raviraj Vankayala, Jenny T. Mac, Taylor Hanley, Bahman Anvari

Author Affiliations +

Proceedings Volume 11660, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII; 1166006 (2021) https://doi.org/10.1117/12.2582797
Event: SPIE BiOS, 2021, Online Only

Abstract

We have engineered nano-sized constructs from erythrocytes doped with the FDA-approved near infrared (NIR) chromophore, indocyanine green (ICG). Herein, we present results that demonstrate membrane cholesterol enrichment is associated with reduced uptake of these nanoparticles by macrophages in vitro, and greater accumulation of the nanoparticles in intraperitoneal implants in immunodeficient mice. These preliminary findings suggest that cholesterol-enrichment of erythrocyte-derived optical nanoparticles can provide a potential capability for enhanced NIR imaging of tumors.

Conference Presentation

Citation Download Citation

Chi-Hua Lee, Jack C. Tang, Raviraj Vankayala, Jenny T. Mac, Taylor Hanley, and Bahman Anvari "Cholesterol-enriched erythrocyte-derived optical nanoparticles for NIR fluorescence imaging of intraperitoneal ovarian tumors in mice", Proc. SPIE 11660, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII, 1166006 (16 March 2021); https://doi.org/10.1117/12.2582797

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