Ultra-high-speed wide-field photoacoustic microscopy

Junjie Yao

doi:10.1117/12.2583366

5 March 2021 Ultra-high-speed wide-field photoacoustic microscopy

Junjie Yao

Proceedings Volume 11654, High-Speed Biomedical Imaging and Spectroscopy VI; 1165407 (2021) https://doi.org/10.1117/12.2583366
Event: SPIE BiOS, 2021, Online Only

Abstract

Optical-resolution photoacoustic microscopy (OR-PAM) has become a popular tool in small-animal studies. However, previous OR-PAM techniques variously lacked a high imaging speed, a high spatial resolution, and/or a large field of view. Here we report a high-speed OR-PAM system using an innovative water-immersible polygon-mirror scanner, which has achieved a cross-sectional frame rate of as high as 2400 Hz over a 12-mm scanning range. Using this polygon-scanner-based OR-PAM system, we have performed various studies on mouse models with stroke and cardiac arrests. We expect that the new OR-PAM system will become a powerful tool for imaging hemodynamics and neuronal functions.

Conference Presentation

Citation Download Citation

Junjie Yao "Ultra-high-speed wide-field photoacoustic microscopy", Proc. SPIE 11654, High-Speed Biomedical Imaging and Spectroscopy VI, 1165407 (5 March 2021); https://doi.org/10.1117/12.2583366

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