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5 March 2021 Wide-field imaging of brain white matter fiber tracts with Mueller polarimetry in backscattering configuration
Philippe Schucht, Hee Ryung Lee, Mohammed Hachem Mezouar, Ekkehard Hewer, Andreas Raabe, Michael Murek, Irena Zubak, Johannes Goldberg, Enikö Kövari, Angelo Pierangelo, Tatiana Novikova
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Proceedings Volume 11646, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics; 1164605 (2021) https://doi.org/10.1117/12.2577872
Event: SPIE BiOS, 2021, Online Only
Abstract
The accurate detection of brain tumor border during neurosurgery is crucial for the safe and complete tumor resection, but it is often difficult to differentiate solid tumor tissue from infiltrated white matter. To address this problem we suggest detecting optical anisotropy of brain white matter which consists of bundles of axons (or fiber tracts). Tumor growth erases this optical anisotropy of healthy brain. We used a wide-field imaging Mueller polarimeter to measure thick fixed human and fresh animal brain sections in reflection. The maps of azimuth of fast optical axis of linear birefringent medium obtained from Lu-Chipman decomposition of the experimental Mueller matrices showed a compelling correlation with the fiber tracts directions on histology image of thin whole mount silver-stained brain tissue section.
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Philippe Schucht, Hee Ryung Lee, Mohammed Hachem Mezouar, Ekkehard Hewer, Andreas Raabe, Michael Murek, Irena Zubak, Johannes Goldberg, Enikö Kövari, Angelo Pierangelo, and Tatiana Novikova "Wide-field imaging of brain white matter fiber tracts with Mueller polarimetry in backscattering configuration", Proc. SPIE 11646, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics, 1164605 (5 March 2021); https://doi.org/10.1117/12.2577872
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KEYWORDS
Brain
Neuroimaging
Polarimetry
Tissue optics
Tumors
Backscatter
Anisotropy
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