Quantitative characterization technique for assessment of malignancy in breast fine needle aspirations

Peter Jermain; Dina Kandil; Alona Muzikansky; Ashraf Khan; Anna N. Yaroslavsky

doi:10.1117/12.2577656

5 March 2021 Quantitative characterization technique for assessment of malignancy in breast fine needle aspirations

Peter Jermain, Dina Kandil, Alona Muzikansky, Ashraf Khan, Anna N. Yaroslavsky

Proceedings Volume 11646, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics; 1164604 (2021) https://doi.org/10.1117/12.2577656
Event: SPIE BiOS, 2021, Online Only

Abstract

The aim of this study was to demonstrate the feasibility of methylene blue (MB) fluorescence polarization (Fpol) imaging for reliable detection of breast cancer at the cellular level. Breast cells were collected from discarded malignant, benign, and normal breast tissues following surgery. MB co-/cross-polarized fluorescence emission and Fpol images provided complimentary morphological and quantitative evaluations of the samples, respectively. Statistical analysis confirmed that MB Fpol is significantly higher (P<.0001) in cancerous versus noncancerous cells. This technique may provide a rapid and accurate tool to assist cytopathological differentiation of breast lesions.

Conference Presentation

Citation Download Citation

Peter Jermain, Dina Kandil, Alona Muzikansky, Ashraf Khan, and Anna N. Yaroslavsky "Quantitative characterization technique for assessment of malignancy in breast fine needle aspirations", Proc. SPIE 11646, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics, 1164604 (5 March 2021); https://doi.org/10.1117/12.2577656

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