A wearable fiber-free optical sensor for continuous monitoring of cerebral blood flow in freely moving mice

Xuhui Liu; Chong Huang; Yutong Gu; Elie Abu Jawdeh; Henrietta Bada; Kevin Donohue; Lei Chen; Guoqiang Yu

doi:10.1117/12.2577309

5 March 2021 A wearable fiber-free optical sensor for continuous monitoring of cerebral blood flow in freely moving mice

Xuhui Liu, Chong Huang, Yutong Gu, Elie Abu Jawdeh, Henrietta Bada, Kevin Donohue, Lei Chen, Guoqiang Yu

Author Affiliations +

Proceedings Volume 11638, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables II; 116380A (2021) https://doi.org/10.1117/12.2577309
Event: SPIE BiOS, 2021, Online Only

Abstract

We present an innovative, wearable, fiber-free, near-infrared diffuse speckle contrast flowmetry (DSCF) probe that is fixed on the skull for continuous monitoring of cerebral blood flow (CBF) variations in mice during anesthesia, awake, and freely behaving. Results show a small surge when the animal waked up, a mild decrease after the isoflurane washed off, a 37 ± 9% increase during 10%CO₂ inhalation (n = 3), and mild elevations during grooming and walking. These CBF variations are consistent with clinical observations when recovery from anesthesia and impacts by isoflurane, hypercapnia (CO2), and activity-induced cortical excitations.

Conference Presentation

Citation Download Citation

Xuhui Liu, Chong Huang, Yutong Gu, Elie Abu Jawdeh, Henrietta Bada, Kevin Donohue, Lei Chen, and Guoqiang Yu "A wearable fiber-free optical sensor for continuous monitoring of cerebral blood flow in freely moving mice", Proc. SPIE 11638, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables II, 116380A (5 March 2021); https://doi.org/10.1117/12.2577309

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available