Characterization of cerebral blood flow quantification with diffuse correlation spectroscopy in the presence of systemic physiology cross-talk during a hypercapnic challenge

Stefan A. Carp; Melissa M. Wu; Suk-Tak Chan; Dibbyan Mazumder; Davide Tamborini; Kimberly A. Stephens; Bin Deng; Parya Farzam; Yawei Chu; Jason Z. Qu; Maria A. Franceschini

doi:10.1117/12.2579027

5 March 2021 Characterization of cerebral blood flow quantification with diffuse correlation spectroscopy in the presence of systemic physiology cross-talk during a hypercapnic challenge

Stefan A. Carp, Melissa M. Wu, Suk-Tak Chan, Dibbyan Mazumder, Davide Tamborini, Kimberly A. Stephens, Bin Deng, Parya Farzam, Yawei Chu, Jason Z. Qu, Maria A. Franceschini

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Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116291E (2021) https://doi.org/10.1117/12.2579027
Event: SPIE BiOS, 2021, Online Only

Abstract

Non-invasive monitoring of cerebral blood flow at the bedside using diffuse correlation spectroscopy is being investigated as a potential tool to improve brain health outcomes after surgery. In this work we characterize the performance of diffuse correlation spectroscopy measurements in assessing cerebral blood flow in the presence of systemic physiology interference through measurements on several healthy volunteers during CO2 inhalation. We report group averaged responses and the role of multi-layer models in increasing the accuracy of CBF estimates. We compare optical blood flow recordings with transcranial Doppler ultrasound and MRI ASL data.

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Stefan A. Carp, Melissa M. Wu, Suk-Tak Chan, Dibbyan Mazumder, Davide Tamborini, Kimberly A. Stephens, Bin Deng, Parya Farzam, Yawei Chu, Jason Z. Qu, and Maria A. Franceschini "Characterization of cerebral blood flow quantification with diffuse correlation spectroscopy in the presence of systemic physiology cross-talk during a hypercapnic challenge", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116291E (5 March 2021); https://doi.org/10.1117/12.2579027

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KEYWORDS

Cerebral blood flow

Spectroscopy

Physiology

Tissue optics

Carbon dioxide

Monte Carlo methods

Optical testing

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