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Intraoperative nerve recognition is critical to avoid accidental transection. Fluorescence-guided surgery can aid in nerve identification. However, detection of weak nerve-specific fluorescence signal is susceptible to the interference from high-background bright lights. We present a time-gated imager designed with ease-of-use and cost effectiveness in mind. Using this technology, we demonstrate successful rejection of room-light background signal to visualize the murine sciatic nerve.
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Mark T. Scimone, Youbo Zhao, Jason R. Gunn, Brian W. Pogue, Nicusor V. Iftimia, "Low-cost time-gated imager for intraoperative nerve identification," Proc. SPIE 11625, Molecular-Guided Surgery: Molecules, Devices, and Applications VII, 116250H (5 March 2021); https://doi.org/10.1117/12.2582710