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5 March 2021 Novel use of Confocal Raman Spectroscopy for in vivo quantification of skin permeants in real time: a non-invasive method for assessing bioequivalence
Fotis Iliopoulos, Peter J. Caspers, Gerwin J. Puppels, Majella E. Lane
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Proceedings Volume 11624, Visualizing and Quantifying Drug Distribution in Tissue V; 1162407 (2021) https://doi.org/10.1117/12.2582825
Event: SPIE BiOS, 2021, Online Only
Abstract
Confocal Raman spectroscopy (CRS) enables the real-time profiling of substances penetrating to the skin without sample pre-treatment or labelling. Until now, CRS had been used as a semi-quantitative method, which posed challenges for evaluating topical formulations and assessing bioequivalence. We present a novel approach of CRS for quantitative analysis of skin delivery. The quantitative CRS in vivo has been correlated with the well-established in vitro Franz-diffusion experiments, indicating the potential of CRS for determining skin delivery. We anticipate CRS providing a rapid and non-invasive method that will be an attractive alternative to the clinical studies currently used in bioequivalence testing.
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Fotis Iliopoulos, Peter J. Caspers, Gerwin J. Puppels, and Majella E. Lane "Novel use of Confocal Raman Spectroscopy for in vivo quantification of skin permeants in real time: a non-invasive method for assessing bioequivalence", Proc. SPIE 11624, Visualizing and Quantifying Drug Distribution in Tissue V, 1162407 (5 March 2021); https://doi.org/10.1117/12.2582825
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KEYWORDS
Skin
Chromium
Confocal microscopy
Raman spectroscopy
In vivo imaging
In vitro testing
Profiling
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