Receiver operating characteristics analysis of Surface Enhanced Raman Spectroscopy (SERS) sensors

Li-Lin Tay; John Hulse; Shawn Poirier; Ali Ghaemi

doi:10.1117/12.2580085

8 November 2020 Receiver operating characteristics analysis of Surface Enhanced Raman Spectroscopy (SERS) sensors

Li-Lin Tay, John Hulse, Shawn Poirier, Ali Ghaemi

Proceedings Volume 11525, SPIE Future Sensing Technologies; 1152507 (2020) https://doi.org/10.1117/12.2580085
Event: SPIE Future Sensing Technologies, 2020, Online Only

Abstract

Inkjet-printed surface enhanced Raman spectroscopy (SERS) sensors are fabricated on cellulose based paper or fabric substrates. These flexible sensors provides basic point-of-sampling advantages that is particularly useful in field applications. Due to the heterogeneous loading of nanoparticles on the substrate, SERS intensities inevitably vary across the active area of the printed sensor. This paper will discuss the use of receiver operating characteristics (ROC) for the analysis of inkjet-printed SERS sensors. The aim is to provide an alternative measurand to the SERS enhancement factor that can be used to compare different types of SERS substrates. We have developed statistical analysis from multiple data sets obtained from sensors exposed to both analyte and control to determine the probability of positive detection (PD) at various analyte concentration. This dependence describes the ROC of the sensor and also provides confidence level associated with a given detection limit. We propose this methodology for the evaluation of SERS sensors to enable their field applications.

Conference Presentation

Citation Download Citation

Li-Lin Tay, John Hulse, Shawn Poirier, and Ali Ghaemi "Receiver operating characteristics analysis of Surface Enhanced Raman Spectroscopy (SERS) sensors", Proc. SPIE 11525, SPIE Future Sensing Technologies, 1152507 (8 November 2020); https://doi.org/10.1117/12.2580085

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