The peculiarity and influencing factors of red blood cell interaction in individual cell pairs studied by optical tweezers

Ruixue Zhu; Tatiana Avsievich; Alexey Popov; Igor Meglinski

doi:10.1117/12.2568515

20 August 2020 The peculiarity and influencing factors of red blood cell interaction in individual cell pairs studied by optical tweezers

Ruixue Zhu, Tatiana Avsievich, Alexey Popov, Igor Meglinski

Author Affiliations +

Proceedings Volume 11463, Optical Trapping and Optical Micromanipulation XVII; 114630I (2020) https://doi.org/10.1117/12.2568515
Event: SPIE Nanoscience + Engineering, 2020, Online Only

Abstract

Optical Tweezers (OTs) is not only a novelty in laser physics but also an indispensable tool in cell biology studies, especially in the precise manipulation of single living cells and detection of ultra-low intercellular bio-forces. The reversible aggregation of red blood cells (RBCs) strongly influences the blood rheological properties and is critical for blood microcirculation monitoring and therapy. However, the mechanism behind and the factors influencing the aggregation dynamics are still not clear. In this study, the peculiarity of red blood cell interaction was investigated and the potential factors influencing the aggregation process were clarified by optical tweezers. The intercellular interaction force in cell pairs, the role of cell deformation and adhesion time in interaction dynamics, as well as the effects of low-level laser irradiation, were evaluated and discussed.

Conference Presentation

Citation Download Citation

Ruixue Zhu, Tatiana Avsievich, Alexey Popov, and Igor Meglinski "The peculiarity and influencing factors of red blood cell interaction in individual cell pairs studied by optical tweezers", Proc. SPIE 11463, Optical Trapping and Optical Micromanipulation XVII, 114630I (20 August 2020); https://doi.org/10.1117/12.2568515

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