Repeatability, reproducibility, and accuracy of a novel imaging technique for measurement of ocular axial length

Neelam Hari; Carrie Burgess; Ehsan Vaghefi

doi:10.1117/12.2560544

28 February 2020 Repeatability, reproducibility, and accuracy of a novel imaging technique for measurement of ocular axial length

Neelam Hari, Carrie Burgess, Ehsan Vaghefi

Author Affiliations +

Proceedings Volume 11317, Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging; 113172D (2020) https://doi.org/10.1117/12.2560544
Event: SPIE Medical Imaging, 2020, Houston, Texas, United States

Abstract

The rise in short-sightedness (myopia) is raising concerns in our global health, impacting an estimated 22.9% of the world’s population in the year 2000.1, 2 We are developing a new method to determine axial length measurements of the eye, addressing the paediatric population. The purpose of this study is to assess the repeatability, reproducibility, and accuracy of our proposed imaging technique for axial length measurements in ex vivo animal eyes and human model eyes. Our non-contact optical system utilizes an 808 nm continuous wave laser. For the animal study, our system employed varying laser powers <0.6 mW, obtaining images of ex vivo porcine eyes. Comparative measurements were taken with MRI of the same samples in similar conditions. Results indicated that our system was both repeatable and reproducible. The trend for accuracy was not evident in animal eyes, but this was due to the variable ex vivo sample quality. For the model eye study, and to mimic clinical conditions, the laser intensity is reduced via optical components resulting in a safe exposure for the human eye, as outlined by IEC 60825-1:2014. This laser exposure includes a beam power of <0.4 mW and exposure time of less than 2 seconds. Data is captured with an infrared camera. Our device will offer a unique and low-cost solution for early detection of myopia in children, helping to timely intervene and ultimately control the looming myopia pandemic.

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Neelam Hari, Carrie Burgess, and Ehsan Vaghefi "Repeatability, reproducibility, and accuracy of a novel imaging technique for measurement of ocular axial length", Proc. SPIE 11317, Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging, 113172D (28 February 2020); https://doi.org/10.1117/12.2560544

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KEYWORDS

Eye

Eye models

Animal model studies

Magnetic resonance imaging

Image acquisition

Cornea

Statistical analysis

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