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28 February 2020 DMD-based rapid 3D bioprinting for precision tissue engineering and regenerative medicine
Claire Yu, Shangting You, Wei Zhu, Bingjie Sun, Shaochen Chen
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Proceedings Volume 11294, Emerging Digital Micromirror Device Based Systems and Applications XII; 1129405 (2020) https://doi.org/10.1117/12.2550340
Event: SPIE OPTO, 2020, San Francisco, California, United States
Abstract
DMD-based 3D printing is a powerful tool for making high-resolution biomimetic functional tissues and organs with various biomaterials for tissue engineering and regenerative medicine. A plethora of tissues have been fabricated using this technology including liver, heart, lung, kidney, blood vessels, cartilage, and placenta. In this article, we show prevascularization of the artificial tissue constructs using DMD-based 3D printing, which is essential to maintain the long term viability and function of a thick tissue. We also show a 3D printed biomimetic hepatic model that recapitulates the microarchitecture as well as the heterogeneous cell population of various cell types in the native liver tissue. It is important for the biomaterials to mimic the native microenvironment. Finally, we demonstrate that 3D printed tissue-specific decellularized extracellular matrix can improve cell response and behavior.
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Claire Yu, Shangting You, Wei Zhu, Bingjie Sun, and Shaochen Chen "DMD-based rapid 3D bioprinting for precision tissue engineering and regenerative medicine", Proc. SPIE 11294, Emerging Digital Micromirror Device Based Systems and Applications XII, 1129405 (28 February 2020); https://doi.org/10.1117/12.2550340
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KEYWORDS
Tissues
3D modeling
Printing
3D printing
In vitro testing
Biomimetics
Liver
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