Terahertz spectrometer based on widely tunable injection-seeded terahertz parametric generation and detection for identifying pharmaceutical materials

M. Mohara; K. Shimura; K. Aiko; T. Ono

doi:10.1117/12.2541794

2 March 2020 Terahertz spectrometer based on widely tunable injection-seeded terahertz parametric generation and detection for identifying pharmaceutical materials

M. Mohara, K. Shimura, K. Aiko, T. Ono

Author Affiliations +

Proceedings Volume 11279, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications XIII; 112790X (2020) https://doi.org/10.1117/12.2541794
Event: SPIE OPTO, 2020, San Francisco, California, United States

Abstract

Terahertz (THz) spectroscopy is expected as a new technique for nondestructive inspection of pharmaceutical tablets, because THz waves pass through a wide variety of pharmaceutical materials. We have been developing a frequency domain THz spectrometer with an injection-seeded THz parametric generation (is-TPG) technique. In this study, the frequency range of the spectrometer was successfully expanded to 0.9-4.2 THz by generating widely tunable THz waves by shifting a nonlinear crystal to balance gain and absorption of the THz waves in the crystal, and detecting the THz waves with an angle-compensation method that utilized the dispersion of the crystal. Absorption spectra of the crystal polymorphs of carbamazepine forms I and III were obtained with the THz spectrometer, and these polymorphs were identified by specific absorption peaks related to their solid state.

Conference Presentation

Citation Download Citation

M. Mohara, K. Shimura, K. Aiko, and T. Ono "Terahertz spectrometer based on widely tunable injection-seeded terahertz parametric generation and detection for identifying pharmaceutical materials", Proc. SPIE 11279, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications XIII, 112790X (2 March 2020); https://doi.org/10.1117/12.2541794

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