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9 March 2020 A computational paper-based point-of-care assay for high-sensitivity c-reactive protein quantification (Conference Presentation)
Zachary Ballard, Hyou-Arm Joung, Artem Goncharov, Jesse Liang, Karina Nugroho, Dino Di Carlo, Omai Garner, Aydogan Ozcan
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Proceedings Volume 11230, Optics and Biophotonics in Low-Resource Settings VI; 112300C (2020) https://doi.org/10.1117/12.2546649
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
We demonstrate a low-cost and rapid paper-based vertical flow assay (VFA) for quantification of C-Reactive Protein (CRP). We use deep learning-based analysis of this VFA and its multiplexed sensing channels to achieve accurate quantification, as well as to overcome fabrication and operational variations along with limitations borne out of the hook effect, validating our results with clinical samples. This computational point-of-care test could be used for stratification of patients into cardiovascular disease risk assessment groups following standard clinical cut-offs. It can also broadly serve as a computational sensing platform for future point-of-care sensing and diagnostic applications.
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Zachary Ballard, Hyou-Arm Joung, Artem Goncharov, Jesse Liang, Karina Nugroho, Dino Di Carlo, Omai Garner, and Aydogan Ozcan "A computational paper-based point-of-care assay for high-sensitivity c-reactive protein quantification (Conference Presentation)", Proc. SPIE 11230, Optics and Biophotonics in Low-Resource Settings VI, 112300C (9 March 2020); https://doi.org/10.1117/12.2546649
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KEYWORDS
Proteins
Point-of-care devices
Chemical vapor deposition
Multiplexing
Arteries
Blood
Diagnostics
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