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We investigated clinical imaging of the human retina with visible-light optical coherence tomography (vis-OCT) with a 1 µm axial resolution. Imaging was performed with rectangular modulation of the scanning beam that reduced image speckle noise and preserved fine anatomical features. B-scans acquired with scan modulation revealed new anatomical features and demonstrated increased contrast to noise ratio (CNR) over regularly acquired B-scans.
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Hao F. Zhang, Ian Rubinoff, Yuanbo Wang, Zeinab Ghassabi, Hiroshi Ishikawa, Joel Schuman, Roman Kuranov, "Ultrahigh-resolution imaging of the human retina with scan modulation visible light optical coherence tomography (Conference Presentation)," Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112280G (9 March 2020); https://doi.org/10.1117/12.2545207