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9 March 2020 Astrocyte sensitivity to pulsed infrared light: molecular, physiological, and mechanistic insights (Conference Presentation)
Wilson R. Adams, Ana I. Borrachero-Conejo, Emanuela Saracino, Manqing Wang, Tamara Posati, Graham A. Throckmorton, John Logan Jenkins, Jeremy B. Ford, Roberto Zamboni, Marco Caprini, Grazia Paola Nicchia, E. Duco Jansen, Valentina Benfenati, Anita Mahadevan-Jansen
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Proceedings Volume 11227, Optogenetics and Optical Manipulation 2020; 112270N (2020) https://doi.org/10.1117/12.2545237
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
We have shown previously that astrocytes are independently sensitive to IR exposure in the context of infrared neural stimulation (INS). More recently, our advances have identified some physiological basis of astrocytic sensitivity to INS. Single pulse INS evokes intracellular calcium signaling primarily mediated through inositol-triphosphate receptor (IP¬3R) activation, rather than thermally sensitive transient receptor protein (TRP) pathways. Interestingly, different dosing strategies for IR appear to evoke different physiology. Our findings suggest that tailoring irradiation parameters with INS may be used for preferentially drive separate physiological responses in astrocytes, and possibly other cell types.
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Wilson R. Adams, Ana I. Borrachero-Conejo, Emanuela Saracino, Manqing Wang, Tamara Posati, Graham A. Throckmorton, John Logan Jenkins, Jeremy B. Ford, Roberto Zamboni, Marco Caprini, Grazia Paola Nicchia, E. Duco Jansen, Valentina Benfenati, and Anita Mahadevan-Jansen "Astrocyte sensitivity to pulsed infrared light: molecular, physiological, and mechanistic insights (Conference Presentation)", Proc. SPIE 11227, Optogenetics and Optical Manipulation 2020, 112270N (9 March 2020); https://doi.org/10.1117/12.2545237
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KEYWORDS
Infrared radiation
Infrared imaging
Brain
Thermography
Calcium
Receptors
In vitro testing
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