Photodynamic therapy: apoptosis, paraptosis, and autophagy

David Kessel; Won Jin Cho; Hyeong-Reh C. Kim

doi:10.1117/12.2543895

19 February 2020 Photodynamic therapy: apoptosis, paraptosis, and autophagy

David Kessel, Won Jin Cho, Hyeong-Reh C. Kim

Proceedings Volume 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX; 1122002 (2020) https://doi.org/10.1117/12.2543895
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Photodynamic therapy (PDT) can elicit different cellular responses depending on sub-cellular sites of photodamage. Targeting lysosomes or mitochondria leadd to death by apoptosis, while ER photodamage can result in apoptosis and paraptosis. Autophagy is cytoprotective unless lysosomes are the primary target. We propose that the optimal targeting profile involves lysosomes, mitochondria and ER. Lysosomal phototoxicity is not limited by autophagy and can promote pro-apoptotic effects that magnify the lethality of mitochondrial photodamage. Targeting ER can be effective even in cells with an impaired apoptotic program since this will not affect paraptotic death.

Citation Download Citation

David Kessel, Won Jin Cho, and Hyeong-Reh C. Kim "Photodynamic therapy: apoptosis, paraptosis, and autophagy", Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 1122002 (19 February 2020); https://doi.org/10.1117/12.2543895

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