9 March 2020Microglia distribution and motility in human eyes measured with adaptive optics – optical coherence tomography (AO-OCT) (Conference Presentation)
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Microglia are central nervous system macrophages and the first responders to neural injury. Herein we characterize their distribution and motility in human eyes using a multimodal AO system. In healthy eyes, microglia are absent in the central macula up to ~5º eccentricity but their density increases monotonically at higher eccentricities. Microglia density decreases linearly with age. ILM microglia are relatively immobile for durations up to two weeks but their processes re-orient over timescales as short as minutes. The density, motility, and reactive state of microglia may serve as an ocular disease biomarker for early detection and progression monitoring.
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Daniel X. Hammer, Ricardo Villanueva, Anant Agrawal, Osamah Saeedi, Zhuolin Liu, "Microglia distribution and motility in human eyes measured with adaptive optics – optical coherence tomography (AO-OCT) (Conference Presentation)," Proc. SPIE 11218, Ophthalmic Technologies XXX, 1121818 (9 March 2020); https://doi.org/10.1117/12.2548639