Optically measuring nerve activity based on an electro-optical detection system

Yuan Wei; Amr Al Abed; Nathalie Gouailhardou; Han Wang; Xinyue Lei; François Ladouceur; Torsten Lehmann; Nigel H. Lovell; Leonardo Silvestri

doi:10.1117/12.2540053

30 December 2019 Optically measuring nerve activity based on an electro-optical detection system

Yuan Wei, Amr Al Abed, Nathalie Gouailhardou, Han Wang, Xinyue Lei, François Ladouceur, Torsten Lehmann, Nigel H. Lovell, Leonardo Silvestri

Author Affiliations +

Proceedings Volume 11202, Biophotonics Australasia 2019; 112021K (2019) https://doi.org/10.1117/12.2540053
Event: ANZCOP, 2019, Melbourne, Australia

Abstract

Nerve conduction and activity is a marker of disease and wellness and provides insight into the complex way the nervous system encodes information. We propose an electro-optical detection system and show the recordings from an electrically stimulated in-vitro nerve preparation. The system converts the action potential at the probing position to light intensity before any amplification and detection. Thence the light signal is detected by a photodetector. The new detection system has the ability of isolating the probing point and the amplification circuits, which reduces the electrical interference from the circuit. Moreover, the sampled signal transmitted via optical fibres rather than cables or wires makes it more robust to environmental noise. From the experiment, we demonstrated that the electro-optical detection system is able to detect and amplify the nerve response. By analysing the data, we can distinguish the response from the stimulus artifact and calculate CAP (compound action potential) propagation speed.

Citation Download Citation

Yuan Wei, Amr Al Abed, Nathalie Gouailhardou, Han Wang, Xinyue Lei, François Ladouceur, Torsten Lehmann, Nigel H. Lovell, and Leonardo Silvestri "Optically measuring nerve activity based on an electro-optical detection system", Proc. SPIE 11202, Biophotonics Australasia 2019, 112021K (30 December 2019); https://doi.org/10.1117/12.2540053

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