Digital holographic microscopy as a screening technology for diabetes

Ana Doblas; Jorge Garcia-Sucerquia; Genaro Saavedra; Manuel Martinez-Corral

doi:10.1117/12.2523416

14 May 2019 Digital holographic microscopy as a screening technology for diabetes

Ana Doblas, Jorge Garcia-Sucerquia, Genaro Saavedra, Manuel Martinez-Corral

Proceedings Volume 10997, Three-Dimensional Imaging, Visualization, and Display 2019; 109970K (2019) https://doi.org/10.1117/12.2523416
Event: SPIE Defense + Commercial Sensing, 2019, Baltimore, MD, United States

Abstract

Label-free quantitative phase imaging (QPI) is the hallmark of digital holographic microscopy (DHM). One of the most interesting medical applications of QPI-DHM is that it can be used to analyze illnesses in which the refractive index or/and the morphology of cells/tissues are distorted, from the acquisition of a single image. In this contribution, we obtain the phase maps of red blood cells (RBCs) samples of patients suffering from diabetes mellitus type 1 (DM1) by using a DHM. Our experimental results show that the measured phase values are significantly different between control non-diabetic and diabetic patients. The high correlation coefficient between the phase and the glycated hemoglobin (HbA1C) values determined by the gold standard method to screen diabetes and the clear separation between the two groups indicate that DHM may potentially be used to evaluate long-term glycemic control in diabetic patients as well as to diagnose diabetes.

Citation Download Citation

Ana Doblas, Jorge Garcia-Sucerquia, Genaro Saavedra, and Manuel Martinez-Corral "Digital holographic microscopy as a screening technology for diabetes", Proc. SPIE 10997, Three-Dimensional Imaging, Visualization, and Display 2019, 109970K (14 May 2019); https://doi.org/10.1117/12.2523416

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available