Sensitivity improved surface plasmon resonance biosensor for cancer biomarker detection based on 2D perovskite-based metasurfaces (Conference Presentation)

Shuwen Zeng

doi:10.1117/12.2504472

13 March 2019 Sensitivity improved surface plasmon resonance biosensor for cancer biomarker detection based on 2D perovskite-based metasurfaces (Conference Presentation)

Shuwen Zeng

Author Affiliations +

Proceedings Volume 10894, Plasmonics in Biology and Medicine XVI; 108940Q (2019) https://doi.org/10.1117/12.2504472
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

In this study, we report the design of a 2D nanomaterial-enhanced biosensor by integrating both the 2D nanomaterials and immunoassay sensing techniques. A phase interrogation surface plasmon resonance (SPR) system was used for detecting antigen with a concentration ranging from nanomolar to femtomolar level. Our work has shown that the evanescent field generated from the Au film to 2D perovskite could lead to a significant sensitivity improvement. This specially antibody-functionalized sensing substrate, embedded with plasmonic metasurface structure, exhibited strong plasmonic coupling effect. And this optimized nanostructure could be engineered as a powerful and ultrasensitive platform for cancer diagnostics. The thickness of the sensing substrate is tuned in an atomic scale and optimized to obtain an enhanced sensing effect. More specifically, a sharp phase signal change and phase-related Goos-Hänchen signal shift was achieved that results from the strong resonance. The improved sensitivities of 2D Perovskite nanostructures were investigated. It is worth noting that the atomic layer design led to the sensing substrate optimized with a tuning scale less than 1 nm. Through a precise engineering of the metasurface substrates, 3 orders of magnitude improvement of the sensitivity (800,000 um/RIU) were demonstrated compared to the one with pure gold sensing substrate (300 um/RIU). This hybrid 2D nanomaterial-based metasurfaces would provide a good opportunity for the development of integrated cancer theranostic devices.

Conference Presentation

Citation Download Citation

Shuwen Zeng "Sensitivity improved surface plasmon resonance biosensor for cancer biomarker detection based on 2D perovskite-based metasurfaces (Conference Presentation)", Proc. SPIE 10894, Plasmonics in Biology and Medicine XVI, 108940Q (13 March 2019); https://doi.org/10.1117/12.2504472

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