Stimulated Raman scattering-spectroscopic optical coherence tomography (SRS-SOCT): theory, applications and new developments

Francisco E. Robles

doi:10.1117/12.2510212

4 March 2019 Stimulated Raman scattering-spectroscopic optical coherence tomography (SRS-SOCT): theory, applications and new developments

Francisco E. Robles

Author Affiliations +

Proceedings Volume 10890, Label-free Biomedical Imaging and Sensing (LBIS) 2019; 108900N (2019) https://doi.org/10.1117/12.2510212
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Stimulated Raman scattering spectroscopic optical coherence tomography (SRS-SOCT) is a recently developed molecular imaging technique that leverages the spatial and spectral multiplexing capabilities of SOCT with the molecular sensitivity and specificity of SRS for fast, tomographic, label-free molecular imaging. Here we present a theoretical framework for SRS-SOCT, discuss its advantages and limitations, and show experimental results from excised human adipose tissue. We also discuss our recent efforts in developing a novel light source, based on a coherently broadened laser, that is specifically tailored for SRS-SOCT. Implications of this label-free, molecular imaging technique for biomedical applications are discussed.

Citation Download Citation

Francisco E. Robles "Stimulated Raman scattering-spectroscopic optical coherence tomography (SRS-SOCT): theory, applications and new developments", Proc. SPIE 10890, Label-free Biomedical Imaging and Sensing (LBIS) 2019, 108900N (4 March 2019); https://doi.org/10.1117/12.2510212

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